apalutamide will lessen the level or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which have been CYP3A4 substrates may result in decreased publicity to these medications.Extreme Anaphylactic and Anaphylactoid Reac